[HCS]

Jenkins should be in the 14th Region and Lawrence County should be in the 16th Region.

Probably true, but you need 16 teams in the 15th if the goal is to be fair to all the regions/teams.

Maybe keep Jenkins and replace Lawrence County with Letcher County then.

I think Knott would make a lot more sense with its connection to Floyd on at least a couple of roads.

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I don't think KHSAA wants to do a new alignment
I've always advocated Harlan County and Harlan with Letcher and Jenkins in the 53rd
I'd move Knott, Cordia and JBS to 15th to give that region enough teams

That would be a thought. It would also be hard on Powell and estill if they had to travel to Harlan and the same if either Harlan team  had to travel to Powell or estill.

Harlan is 143 miles from Irvine and 120 to Stanton. For a comparison with a team already in the 14th, Letcher Central, Whitesburg is 121 miles to Irvine and 101 to Stanton. 
There’s not a huge difference, about 20 miles travel one way. But every region except 6th and 7th have teams located far apart. Think of the 12th with Wayne County  traveling to the Jessamine County schools. Or Clark County’s drive to the northern Kentucky Ohio River schools. Also in the 16th it’s probably a good distance from Greenup County to Menifee and Bath County.

True, plus Harlan County would never HAVE to travel to Estill or Powell or vice versa unless it's a RARE regional tournament at one place or the other. Cawood was once in the same football district as Estill - not a big deal then the way I remember