[LOOKAYANNER]

I think when you're discussing the region one has to first start with who are the most likely teams to make it to the tournament from their district. That's pretty tough in some districts.

My guess is:

53rd Letcher and Knott
54th Perry and Leslie (but Hazard is close)
55th Breathitt and Wolfe
56th Estill and Owsley (most balanced district, Lee is very good, too, with Kash, the best guard in the region)